A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver Cirrhosis
Recruiting now
Conditions studied: Liver Cirrhoses, Hepatocellular Carcinoma (HCC), Sarcopenia in Liver Cirrhosis, Portal Hypertension Related to Cirrhosis, MRI, Ultrasound
In brief
DETECT-HCC-ESLD is a prospective multicenter study designed to examine early detection and risk stratification of hepatocellular carcinoma (HCC) in individuals with advanced liver disease. Adults with cirrhosis of different etiologies are enrolled and followed longitudinally with structured clinical assessments and imaging at predefined intervals. A key objective is to evaluate ultrasound and abbreviated MRI (AMRI) as surveillance modalities for HCC. The study examines detection performance, feasibility, and factors influencing image quality and interpretability. The protocol also includes the study of body composition, focusing on how variations in adiposity and muscle mass may relate to imaging characteristics, disease progression, and HCC risk. Longitudinal clinical and imaging data are used to explore prediction models aimed at identifying patients with differing levels of HCC risk. The study records outcomes such as incident HCC, liver-related complications, and mortality to support analyses of disease trajectories. The DETECT-HCC-ESLD study provides a structured framework for collecting clinical, imaging, and body composition data over time, enabling detailed evaluation of surveillance strategies and risk patterns in advanced liver disease.
Key facts
- Study ID
- NCT07291141
- Run by
- Mattias Ekstedt
- People needed
- 600
- Starts
- 2025-12-18
- Expected to finish
- 2031-12-01
- Last updated by the study team
- 2025-12-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with liver cirrhosis, according to clinical practice. Based on criteria such as elastography, symptoms, biopsy, or radiology.
- Age ≥18 years ≤ 84
- Written informed consent from the participant
You may not qualify if…
- Contraindications for MRI (ferrrous material, claustrophobia)
- Pregnancy
- Diagnosis of primary sclerosing cholangitis (PSC)
- Vascular liver disease
- Congenital liver fibrosis
- Previous diagnosis of hepatic carcinoma (HCC)
- Previous liver transplant
Where it is running
- Department of gastroenterology and hepatology, University hospital in Linköping — Linköping, Select A State Or Province, Sweden (enrolling)
Full record on ClinicalTrials.gov
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