A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

Recruiting now · Not applicable

Conditions studied: Ischemic Stroke

In brief

The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.

Key facts

Study ID

NCT07291024

Run by

Mayo Clinic

People needed

20

Starts

2025-12-03

Expected to finish

2029-01-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Ischemic stroke ≥6 months prior to enrollment.
• Post-stroke lower extremity impairment defined as gait velocity of less than 0.8 m/s on a 10-meter walk test
• Provision of informed consent

You may not qualify if…

• Intracerebral Hemorrhage
• Active or prior psychosis or substance abuse within two years.
• Pre-stroke modified Rankin Scale (mRS) 3-5.
• Unable to participate in in-clinic rehabilitation.
• Preexisting neurological disorders affecting gait and mobility, such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), dementia, major head trauma.

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.