A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults

Recruiting now · Phase 1

Conditions studied: Psoriatic Arthritis, Axial Spondyloarthritis

In brief

To demonstrate that bimekizumab administered intravenously is noninferior to subcutaneous administration.

Key facts

Study ID

NCT07290036

Run by

UCB Biopharma SRL

People needed

392

Starts

2025-12-10

Expected to finish

2028-09-14

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be 18+ years old and legally able to consent
• Have active psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA), suitable for bimekizumab treatment
• Weigh between 45-100 kg (females) or 50-100 kg (males).
• Be biologic disease-modifying anti-rheumatic drug (bDMARD)-naïve or have stopped bDMARDs ≥3 months or 5 half-lives ago

You may not qualify if…

• Serious organ system disorders (e.g., heart, liver, kidney, gastrointestinal, neuro)
• Severe psychiatric issues or substance abuse in the past year
• Recent or chronic infections, including tuberculosis (TB) or nontuberculous mycobacterium (NTMB)
• Other inflammatory diseases (e.g., rheumatoid arthritis (RA), lupus, inflammatory bowel disease (IBD))
• Recent live vaccines (within 8 weeks) or Bacillus Calmette-Guerin (BCG) (within 1 year)
• Recent use of glucagon-like peptide-1 (GLP-1) agonists (within 28 weeks)

Where it is running

• Pa0019 127 — Apple Valley, California, United States (enrolling)
• Pa0019 111 — Covina, California, United States (enrolling)
• Pa0019 119 — Fullerton, California, United States (enrolling)
• Pa0019 117 — Riverside, California, United States (enrolling)
• Pa0019 125 — San Leandro, California, United States (enrolling)
• Pa0019 126 — Temecula, California, United States (enrolling)
• Pa0019 141 — Upland, California, United States (enrolling)
• Pa0019 120 — Whittier, California, United States (enrolling)
• Pa0019 128 — Whittier, California, United States (enrolling)
• Pa0019 123 — Fort Collins, Colorado, United States (enrolling)
• Pa0019 143 — Ormond Beach, Florida, United States (enrolling)
• Pa0019 113 — South Miami, Florida, United States (enrolling)
• Pa0019 133 — Zephyrhills, Florida, United States (enrolling)
• Pa0019 132 — Chicago, Illinois, United States (enrolling)
• Pa0019 134 — Lansing, Michigan, United States (enrolling)
• Pa0019 140 — West Long Branch, New Jersey, United States (enrolling)
• Pa0019 131 — Albuquerque, New Mexico, United States (enrolling)
• Pa0019 144 — Vandalia, Ohio, United States (enrolling)
• Pa0019 115 — Duncansville, Pennsylvania, United States (enrolling)
• Pa0019 142 — Rock Hill, South Carolina, United States (enrolling)
• Pa0019 116 — Jackson, Tennessee, United States (enrolling)
• Pa0019 138 — Murfreesboro, Tennessee, United States (enrolling)
• Pa0019 129 — Baytown, Texas, United States (enrolling)
• Pa0019 136 — Colleyville, Texas, United States (enrolling)
• Pa0019 114 — Peoria, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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