Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and Lumbar Decompression Fusion Surgery in the Treatment of Degenerative Lumbar Spondylolisthesis
Recruiting now
Conditions studied: Lumbar Degenerative Spondylolisthesis
In brief
This study aims to systematically evaluate the therapeutic efficacy of dual-channel endoscopic spinal decompression versus lumbar decompression with fusion for degenerative lumbar spondylolisthesis. Patients undergoing either procedure will undergo detailed preoperative and postoperative follow-up to compare outcomes between the two techniques, specifically assessing postoperative pain relief, neurological improvement, and the incidence of surgical complications.
Key facts
- Study ID
- NCT07289737
- Run by
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
- People needed
- 100
- Starts
- 2025-12-10
- Expected to finish
- 2030-06-30
- Last updated by the study team
- 2025-12-17
Who can join
Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged between 50 and 90 years old with a confirmed diagnosis of degenerative lumbar spondylolisthesis;
- Clinical symptoms include chronic pain, nerve compression, or motor dysfunction, confirmed by imaging studies (e.g., MRI or CT);
- No significant improvement after at least 3 months of conservative treatment (e.g., medication, physical therapy), meeting surgical indications;
- Understand and consent to the relevant procedures of this study, and sign the informed consent form.
You may not qualify if…
- Patients exhibiting acute spinal cord compression symptoms or requiring urgent surgical intervention;
- Patients with a history of spinal surgery or conditions such as spinal deformities, severe osteoporosis, or active infections that may compromise surgical outcomes;
- Patients with severe comorbidities affecting assessment, such as cardiovascular disease, liver or kidney failure, or uncontrolled diabetes;
- Patients with psychiatric disorders or cognitive impairments preventing understanding or cooperation with the study process;
- Patients with allergies to anesthetics or surgical equipment that may increase intraoperative risks.
Where it is running
- 4th Affiliated Hospital, School of Medicine, Zhejiang University — Yiwu, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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