Clinical Trial of Vormatrigine in Adult Patients With Epilepsy

Enrolling by invitation · Phase 3

Conditions studied: Epilepsy, Tonic-Clonic, Focal Seizure, Primary Generalized Seizure

In brief

Open Label Extension Clinical Trial of Vormatrigine in Adult Patients with Epilepsy

Key facts

Study ID

NCT07287163

Run by

Praxis Precision Medicines

People needed

700

Starts

2025-10-27

Expected to finish

2028-12-31

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant who completed an eligible clinical trial (unless agreed by the sponsor medical monitor), including PRAX-628-212, PRAX-628-321 or other vormatrigine trials, or participant who has received vormatrigine outside of an eligible clinical trial (such as an expanded access program)
• Participant who had adequate seizure diary and vormatrigine adherence and had been otherwise adherent to the study procedures in the opinion of the investigator unless deemed unacceptable by sponsor

You may not qualify if…

• Participant who withdrew or discontinued treatment from the treatment period of an eligible clinical trial unless deemed acceptable by the sponsor
• Participant who plans to enter another interventional investigational study or is on any prohibited medication
• Participant who is pregnant, lactating or planning to become pregnant
• Participant who is ineligible for the extension clinical trial in the view of the investigator

Where it is running

• Praxis Research Site — Miami, Florida, United States
• Praxis Research Site — Miami Lakes, Florida, United States
• Praxis Research Site — Naples, Florida, United States
• Praxis Research Site — Lafayette, Louisiana, United States
• Praxis Research Site — Bethesda, Maryland, United States
• Praxis Research Site — Plymouth, Michigan, United States
• Praxis Research Site — Chesterfield, Missouri, United States
• Praxis Research Site — Hackensack, New Jersey, United States
• Praxis Research Site — Amherst, New York, United States
• Praxis Research Site — Middletown, New York, United States
• Praxis Research Site — New York, New York, United States
• Praxis Research Site — Niagara Falls, New York, United States
• Praxis Research Site — Philadelphia, Pennsylvania, United States
• Praxis Research Site — El Paso, Texas, United States
• Praxis Research Site — Houston, Texas, United States
• Praxis Research Site — Porto Alegre, Rio Grande do Sul, Brazil
• Praxis Research Site — São José do Rio Preto, São Paulo, Brazil
• Praxis Research Site — Bielefeld, Germany
• Praxis Research Site — Tübingen, Germany
• Praxis Research Site — Pozzilli, Isernia, Italy
• Praxis Research Site — Bosisio Parini, Lecco, Italy
• Praxis Research Site — Milan, Italy
• Praxis Research Site — Naples, Italy
• Praxis Research Site — Pavia, Italy
• Praxis Research Site — Pisa, Italy

Full record on ClinicalTrials.gov

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