Creatine HCl Supplementation in Sarcopenia: A Randomized Controlled Study

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Sarcopenia

In brief

The CONCRET-SARCOPA trial is a 12-week, double-blind, randomized controlled study designed to evaluate the efficacy of creatine HCl supplementation in older adults with sarcopenia. The trial investigates whether daily creatine HCl improves body composition, enhances functional muscle and cognitive performance, and favorably alters key blood biomarkers associated with muscle health and metabolic status. Additionally, the study assesses changes in tissue creatine levels using non-invasive and biochemical methods to clarify mechanistic responses to supplementation. Findings from this trial will provide critical evidence on the therapeutic potential of creatine HCl as a targeted nutritional strategy for managing sarcopenia in the geriatric population.

Key facts

Study ID

NCT07285226

Run by

Center for Health Sciences, Serbia

People needed

30

Starts

2025-12-01

Expected to finish

2026-09-15

Last updated by the study team

2026-01-02

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 60 years
• Low muscle strength by handgrip (SDOC criteria for sarcopenia): < 35.5 kg in men and < 20 kg in women
• Sign free and informed consent
• Demonstrate interest, conditions and availability to participate

You may not qualify if…

• Patients undergoing interventional treatment for sarcopenia
• Physical amputation
• Cognitive impairment (MSSE < 25)
• Unwillingness to return for follow-up analysis
• Participation in other clinical trials

Where it is running

• Center for Health Sciences — Belgrade, Serbia (enrolling)

Full record on ClinicalTrials.gov

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