Histamines and Central Hemodynamics
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Histamine, Exercise
In brief
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise. When the actions of histamine, a molecule primarily known for its role in allergies, are blocked, there is an attenuated blood flow response following exercise. However, this effect has never been studied in the blood vessels that supply our lungs. The purpose of this study is to examine the effects of histamines on pulmonary hemodynamics following exercise.
Key facts
- Study ID
- NCT07285031
- Run by
- University of British Columbia
- People needed
- 20
- Starts
- 2025-12-01
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2025-12-23
Who can join
Age: 19 and older, up to 39. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age: 19 - 39.
- Willing to visit the lab on 3 separate occasions.
You may not qualify if…
- Previously diagnosed heart condition,
- Previously diagnosed lung condition (including asthma),
- Previously diagnosed metabolic condition,
- Currently smokers (cigarettes, electronic cigarettes, cannabis) or who have smoked within the last 3 months,
- Resting blood pressure >140/90 mmHg,
- Unable to obtain appropriate quality ultrasound images of the heart.,
- Individuals without tricuspid regurgitation at rest to allow assessment of the primary outcome,
- Pregnant or trying to become pregnant,
- Breastfeeding,
- Chronically take antihistamines (i.e. daily),
- History of adverse reactions to antihistamines,
- Never taken antihistamines previously,
- Currently taking any medications (including oral contraceptives).
Where it is running
- University of British Columbia — Kelowna, British Columbia, Canada (enrolling)
Full record on ClinicalTrials.gov
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