A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: CRC (Colorectal Cancer)

In brief

The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.

Key facts

Study ID

NCT07284849

Run by

Incyte Corporation

People needed

700

Starts

2026-03-05

Expected to finish

2029-09-28

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Stage IV colorectal adenocarcinoma not amenable to curative resection.
• No prior systemic treatment for unresectable or metastatic disease. Participants who received adjuvant or neoadjuvant therapy may enroll if there was no recurrence within 12 months of the end of treatment.
• Measurable disease per RECIST v1.1.
• ECOG performance status of 0 or 1.
• Adequate organ function determined by laboratory results.

You may not qualify if…

• MSI-H/dMMR per historical data in the medical record.
• BRAF V600E mutation per historical data in the medical record.
• Untreated and/or progressing CNS metastases.
• History of other malignancy within 2 years.
• Treatment with an anti-PD-(L)1 or other immune checkpoint inhibitor for any indication within the last 3 years.
• Active autoimmune disease that has required systemic treatment in the past 2 years.
• Significant concurrent and/or uncontrolled medical condition.
• History of organ transplant, including allogeneic stem cell transplantation.
• Other protocol-defined inclusion/exclusion criteria apply.

Where it is running

• Presbyterian Rust Medical Center — Rio Rancho, New Mexico, United States (enrolling)
• Alliance Cancer Specialists — Doylestown, Pennsylvania, United States (enrolling)
• St. Joseph Mercy Hospital — Ann Arbor, Michigan, United States (enrolling)
• Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
• Ny Cancer and Blood Specialists — Shirley, New York, United States (enrolling)
• The University of North Carolina At Chapel Hill — Chapel Hill, North Carolina, United States (enrolling)
• Hematology Oncology of Indiana — Indianapolis, Indiana, United States (enrolling)
• Sarah Cannon Research Institute Scri Oncology Partners — Brandywine, Maryland, United States (enrolling)
• Missouri Cancer Associates — Columbia, Missouri, United States (enrolling)
• Oncology Hematology Associates — Springfield, Missouri, United States (enrolling)
• Cancer & Blood Research Center — Los Alamitos, California, United States (enrolling)
• Sylvester Comprehensive Cancer Center — Miami, Florida, United States (enrolling)
• Roche Tissue Diagnostics, Companion Diagnostics — Tucson, Arizona, United States (enrolling)
• Messino Cancer Center — Asheville, North Carolina, United States (enrolling)
• Ascension Sacred Heart Pensacola — Pensacola, Florida, United States (enrolling)
• Sarah Cannon Research Institute Scri Oncology Partners — Aurora, Colorado, United States (enrolling)
• Memorial Care Orange Coast Medical Center — Fountain Valley, California, United States (enrolling)
• Cancer Center For Blood Disorders A Division of American Oncology Partners P.A — Bethesda, Maryland, United States (enrolling)
• Providence Medical Foundation — Fullerton, California, United States (enrolling)
• Sih Cancer Institute — Carterville, Illinois, United States (enrolling)
• Florida Oncology & Hematology — Fort Myers, Florida, United States (enrolling)
• Midamerica Cancer Care — Kansas City, Missouri, United States (enrolling)
• Springfield Clinic — Springfield, Illinois, United States (enrolling)
• Community Health Network, Inc. — Indianapolis, Indiana, United States (enrolling)
• Allegheny General Hospital Cancer Institute — Pittsburgh, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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