Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial

Recruiting now · Not applicable

Conditions studied: Arthropathy of Hip, Hip Arthropathy, Locoregional Anesthesia, Complication of Anesthesia, Regional Anesthesia Morbidity, Hospital Stay, Length of Stay in Hospital From Time of Surgery Till Discharge, Opioid Consumption

In brief

This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach. Patients will be randomized to receive either a Pericapsular Nerve Group (PENG) block combined with a Lateral Femoral Cutaneous Nerve (LFCN) block, or a PENG block combined with wound infiltration (WI). The primary outcome is postoperative pain intensity at rest, measured by Numerical Rating Scale (NRS) at 6 hours after surgery. Secondary outcomes include dynamic pain scores at 6, 24, and 48 hours, total opioid consumption, time to first rescue analgesia, quadriceps strength, hip flexion angle, length of stay, and adverse events. All procedures are routinely used in clinical practice and carry minimal additional risk. Safety will be continuously monitored by the Principal Investigator and the study team according to an internal Safety Monitoring Plan.

Key facts

Study ID

NCT07284615

Run by

Ospedale Edoardo Bassini

People needed

102

Starts

2026-01-26

Expected to finish

2026-11-01

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years
• Elective total hip arthroplasty
• Spinal (subarachnoid) anesthesia
• Written informed consent provided by the patient or by the legal guardian, if appointed

You may not qualify if…

• INR > 1.5
• aPTT > 1.5
• Platelet count < 75,000/mm³
• Signs suggestive of infection at the puncture site
• Absence of informed consent to the procedure
• Documented or suspected allergy to local anesthetics

Where it is running

• Ospedale Edoardo Bassini — Cinisello Balsamo, Milano, Italy (enrolling)

Full record on ClinicalTrials.gov

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