A Phase IB Trial of Subcutaneous Blinatumomab in Combination With Revumenib for Patients With KMT2A-rearranged Acute Lymphoblastic Leukemia
Starting soon · Phase 1
Conditions studied: Blinatumomab, Revumenib, Lymphoblastic Leukemia, KMT2A-rearranged
In brief
To learn about the safety and effects of revumenib in combination with blinatumomab in patients with newly diagnosed or relapsed/refractory Ph-negative ALL with a KMT2A rearrangement.
Key facts
- Study ID
- NCT07283640
- Run by
- M.D. Anderson Cancer Center
- People needed
- 20
- Starts
- 2026-11-18
- Expected to finish
- 2031-08-31
- Last updated by the study team
- 2026-06-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Active serious infection not controlled by oral or IV antibiotics
- Active secondary malignancy other than skin cancer (basal cell carcinoma or squamous cell carcinoma) that in the investigator's opinion will shorten survival to less than 1 year
- Participants with psychiatric illness that would limit compliance with study requirements
- Untreated CNS disease. Participants with controlled CNS disease may be included (as defined by being asymptomatic and having CNS cleared of leukemic involvement)
- Detectable HIV viral load within the previous 6 months. Participants with a known history of HIV must have viral load testing prior to study enrollment.
- Any of the following within 6 months prior to study entry: myocardial infarction, congestive heart failure New York Heart Association Classification Class > II, life-threatening, uncontrolled arrhythmia, cerebrovascular accident, or transient ischemic attack
- QTc using Friderica's correction (QTcF) >450 msec
- Personal of family history of long QT syndrome
- Cirrhosis with a Child Pugh score of B or C
- Participants with active hepatitis B (defined as Hepatitis B surface antigen with detectable Hepatitis B virus DNA by PCR) or hepatitis C infection (defined as presence of detectable Hepatitis C virus RNA by PCR)
Where it is running
- MD Anderson Cancer — Houston, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.