A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Overweight, Obesity

In brief

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo for body weight reduction in participants with overweight or obesity and type 2 diabetes. Participation in the study will last about 75 weeks.

Key facts

Study ID

NCT07282600

Run by

Eli Lilly and Company

People needed

1035

Starts

2025-12-15

Expected to finish

2028-02-01

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have type 2 diabetes
• Are on stable treatment for type 2 diabetes for at least 90 days prior to screening
• Have a BMI ≥ 27 kg/m2
• Have a stable body weight (<5% body weight change) for 90 days prior to screening

You may not qualify if…

• Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
• Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
• Have type 1 diabetes
• Have taken any of the following antihyperglycemic medications within 90 days before screening:
• amylin analogs
• glucagon-like peptide-1 (GLP-1) receptor agonists
• glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP) receptor agonists, or
• insulin
• Have had within 90 days prior to screening:
• heart attack
• stroke
• coronary artery revascularization
• unstable angina, or
• hospitalization due to congestive heart failure
• Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
• Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Where it is running

• Cullman Clinical Trials — Cullman, Alabama, United States (enrolling)
• Tucson Clinical Research Institute — Tucson, Arizona, United States (enrolling)
• San Fernando Valley Health Institute — Canoga Park, California, United States (enrolling)
• AMCR Institute — Escondido, California, United States (enrolling)
• NorCal Medical Research, Inc — Greenbrae, California, United States (enrolling)
• Ark Clinical Research — Long Beach, California, United States (enrolling)
• Pacific Clinical Studies — Los Alamitos, California, United States (enrolling)
• Inglewood Clinical — Los Angeles, California, United States (enrolling)
• Care Access - Santa Clarita — Santa Clarita, California, United States (enrolling)
• Encompass Clinical Research — Spring Valley, California, United States (enrolling)
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States (enrolling)
• Care Access - Aurora — Aurora, Colorado, United States (enrolling)
• New England Research Associates, LLC — Bridgeport, Connecticut, United States (enrolling)
• CMR of Greater New Haven, LLC — Hamden, Connecticut, United States (enrolling)
• Arrow Clinical Trials — Daytona Beach, Florida, United States (enrolling)
• Care Access - Delray Beach — Delray Beach, Florida, United States (enrolling)
• Fleming Island Center for Clinical Research — Fleming Island, Florida, United States (enrolling)
• Nature Coast Clinical Research - Inverness — Inverness, Florida, United States (enrolling)
• Jacksonville Center for Clinical Research — Jacksonville, Florida, United States (enrolling)
• Flourish Research Acquisition, LLC dba Flourish Research - North Miami — Miami, Florida, United States (enrolling)
• New Horizon Research Center — Miami, Florida, United States (enrolling)
• Adult Medicine of Lake County, Inc. — Mt. Dora, Florida, United States (enrolling)
• American Research Centers of Florida — Pembroke Pines, Florida, United States (enrolling)
• Clinical Site Partners, LLC dba Flourish Research — Winter Park, Florida, United States (enrolling)
• Birmingham Clinical Research — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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