Testing the Impact of Pre-visit Priming for Medications
Enrolling by invitation · Not applicable
Conditions studied: Deprescribing, Statin Prescribing
In brief
We will use EHR data to identify eligible patients at BWH primary care clinics. Patients will be eligible if they have an upcoming primary care provider (PCP) appointment at an included BWH clinic, are ≥65 years, and are eligible for a medication target; exclusion criteria will include relevant EHR-documented allergies. After sharing patients with PCPs for potential opt-out, patients will be randomized 1:1 in REDCap® to intervention or usual care (no prompt). The intervention will include a pre-visit patient-facing prompt with information about the evidence-based medication target. If patients are eligible for multiple targets, one will be randomly selected. The primary clinical outcome will be measured on the day of the PCP visit using EHR data, depending on target: a) discontinuation or tapering order, or b) prescribing. Secondary outcomes will include a) these same measures in a 60-day follow-up period after the visit to capture any follow-up actions. We will use an intention-to-treat approach including patients regardless of whether the visit occurred. We plan to conduct the trial until 1700 patients are reached. We will also conduct exploratory mediation analyses of mechanisms through brief patient surveys with behavioral scales and PCP survey.
Key facts
- Study ID
- NCT07281131
- Run by
- Brigham and Women's Hospital
- People needed
- 1700
- Starts
- 2026-06-10
- Expected to finish
- 2026-11-14
- Last updated by the study team
- 2026-06-15
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥65 years of age
- Have an upcoming clinic appointment with a BWH PCP at one of the included clinics
- In addition, they must meet the following eligibility criteria for at least one medication target behavior (based on EHR data):
- Statin use for primary prevention (65-75 years of age): Having a EHR diagnosis or problem list documentation of: diabetes, hypertension, smoking, or high cholesterol and estimated eligible cardiovascular risk
- High-risk medication use (≥65 years of age): Have an active outpatient prescription for ≥1 medication on the American Geriatrics Society Beers Criteria® List for Avoid Medications based on EHR records
You may not qualify if…
- Documented allergy to one of the components (statin)
- Current or recent prescription for a statin or PCSK9-inhibitor or bempedoic acid
- Primary language recorded other than English or Spanish
Where it is running
- Mass General Brigham — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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