E-PRF vs Collagen Membranes in Ridge Preservation

Completed · Not applicable

Conditions studied: Ridge Preservation

In brief

Dental implants are often considered the gold standard to replace missing teeth. Having success with dental implants depends on the hard tissue and soft tissue remaining after tooth extractions. The first step to successful dental implant placement begins with proper socket grafting which includes placing a bone graft and membrane among other biomaterials such as platelet-rich fibrin (PRF) to prevent the collapse of the ridge that occurs after a dental extraction. While platelet-rich fibrin is commonly utilized for ridge preservation, it is often used in conjunction with a collagen membrane due to the fact that it has a short resorption time lasting roughly 2 weeks. However, recently, it was discovered that by heating the plasma layer and denaturing the albumin, the resorption properties of PRF could be extended from 2 weeks to 4-6 months. This extended platelet-rich fibrin (e-PRF) membrane is a promising replacement to collagen membranes in various surgeries. The investigators previously demonstrated that e-PRF is a safe and feasible alternative to conventional membranes with 4 different iterations of applying the novel e-PRF membrane. However, there still lacks a comparative study to traditional collagen membranes and between the 4 different iterations. Four different techniques utilizing e-PRF membranes for ridge augmentation will be performed with a collagen membrane as a control group. These techniques include 1) e-PRF as a sole barrier membrane, 2) layering a solid-PRF membrane over the e-PRF membrane, 3) fabricating e-PRF intra-orally in gel form as a Bio-Filler, and 4) Fabricating the e-PRF membrane intra-orally under a solid-PRF membrane.

Key facts

Study ID

NCT07281053

Run by

Center for Advanced Rejuvenation and Esthetics

People needed

55

Starts

2025-02-20

Expected to finish

2025-11-06

Last updated by the study team

2025-12-15

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and Female subjects requiring at least one extraction and replacement with a dental implant.
• No contraindications to dental implant placement

You may not qualify if…

• Smokers
• Autoimmune disease or disorder
• Neurologic disease or disorder
• Major mechanical obstruction to the mouth opening
• Acute capsulitis
• Bone metabolic disease
• Current systemic antibiotic treatment or within 3 months prior to the study
• Drug addiction or alcohol abuse
• Pregnancy, planning to become pregnant and or nursing
• Type 1 diabetes Uncontrolled Type 2 diabetes (Anyone with an A1c >= 7%)

Where it is running

• Lakewood Ranch Dental — Sarasota, Florida, United States

Full record on ClinicalTrials.gov

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