ZYNRELEF vs Continuous Catheter for Pain Management Following Shoulder Arthroplasty

Enrolling by invitation · Phase 4

Conditions studied: Total Shoulder Arthroplasty, Pain Management

In brief

The purpose of this study is to determine if local intra-operative application of ZYNRELEF (topical medication) during shoulder replacement surgery improves pain control (as defined by opioid consumption after surgery) compared to the use of an interscalene block with catheter. This is a randomized clinical trial without blinding. Subjects will complete patient reported outcomes before and after surgery. Subjects will track their narcotic use, pain scores and pain satisfaction after surgery.

Key facts

Study ID

NCT07280195

Run by

Washington University School of Medicine

People needed

86

Starts

2026-02-14

Expected to finish

2027-12-01

Last updated by the study team

2026-02-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients 18 years or older
• Indicated to undergo primary total shoulder arthroplasty (anatomic or reverse)

You may not qualify if…

• Any persons unable to consent, will not be eligible
• Patients undergoing revision arthroplasty or reverse shoulder arthroplasty
• Proximal humerus fractures
• Inability to have interscalene anesthetic catheter placement
• Compromised baseline renal function (CrCl < 50)
• BMI > 40
• History of GI bleed, prior duodenal surgery, or gastric sleeve resection
• Current narcotic use or prior consistent narcotic exposure in the last 6 months
• Use of perioperative oral steroid medications
• Active Workman's compensation claim
• Prior shoulder arthroplasty on the contralateral side in which an interscalene catheter was used

Where it is running

• Washington University — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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