Lung Cancer Screening Implementation Project in the Brazilian Public Health Care System (LUSIP)

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Conditions studied: Lung Cancer

In brief

A prospective, longitudinal, single-arm interventional study of lung cancer screening.

Key facts

Study ID

NCT07279948

Run by

AstraZeneca

People needed

477

Starts

2026-08-31

Expected to finish

2027-01-31

Last updated by the study team

2026-08-03

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• In order, to be eligible for the study, patients must fulfill all the following inclusion criteria:
• Age between ≥50 and ≤80 years.
• Be a current smoker or have quit 15 years ago or less.
• Have participated or are currently participating in smoking cessation program.
• Lifetime smoking exposure equal to or greater than 20 pack-year.
• Provided signed informed consent (ICF)

You may not qualify if…

• In order, to be exclude for the study, patients must at least one of the following exclusion criteria:
• Contraindications to the screening examination: (claustrophobic or weighing more than 130 kgs).
• Inability to climb 3 stair steps non-stop (36 steps).
• Disabling dyspnea
• Symptomatic (with signs and symptoms suspicious of breast cancer lung, namely):
• pleuritic chest pain
• rapidly progressive dyspnea of recent onset
• hemoptysis
• unexplained hoarseness, lasting more than 1 month.
• bone pain
• supraclavicular lymphadenopathy or cervical lymphadenopathy persistent
• unexplained weight loss of 5% or more of weight in less than 6 months
• Previous history of malignant neoplasm (excluding non-melanoma skin cancer) diagnosed less than 10 years before the date of the interview;
• Patients with diagnostic of severe psychiatric disease
• Immunosuppressed by illness or drugs.
• Subjected to anterior lung resection even when determined due to an etiology other than malignant neoplasia.
• Person with a serious terminal illness that contraindicates curative lung surgery.

Where it is running

• Research Site — Rio de Janeiro, Brazil

Full record on ClinicalTrials.gov

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