Fisetin in Mild Alzheimer's Disease
Recruiting now · Phase 2
Conditions studied: Alzheimer s Disease, Alzheimer Dementia, Alzheimer Dementia (AD), Alzheimer Disease, Mild Cognitive Disorder, Neurocognitive Disorders, Mild, Neurocognitive Disorder
In brief
This pilot study will evaluate the safety and tolerability of the natural health product, fisetin, in older adults with mild cognitive impairment or mild Alzheimer's disease dementia.
Key facts
- Study ID
- NCT07279714
- Run by
- Sunnybrook Health Sciences Centre
- People needed
- 5
- Starts
- 2026-01-27
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-04-13
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Mild cognitive impairment due to Alzheimer's disease OR mild Alzheimer Dementia
- Moca score of 11 or higher
- Stable psychotropics and cognitive enhancing medications
You may not qualify if…
- Known hypersensitivity or allergy to fisetin
- Presence of any medical condition, or abnormal routine blood test, that the investigator believes would put the subject at risk or would preclude the patient from completing all aspects of the trial
- Unstable medical disorders
- Ongoing treatment for active infection with antibiotics/antifungals
- Ongoing treatment for cancer
- Active alcohol or substance use disorder
- Recent active bleeding
- Patients taking oral anticoagulants, anti-cancer, anti-seizure medications, or other medications that could have a significant interaction with fisetin
- Use within the last month of other senolytic supplements, antioxidant supplements, natural health products
- Other neurologic or neurodegenerative conditions impacting cognition
- Active Major Depressive Episode, active suicidal thoughts or psychosis
- Any thing that would preclude the ability to undergo an MRI scan
Where it is running
- Sunnybrook Research Institute — Toronto, Ontario, Canada (enrolling)
Full record on ClinicalTrials.gov
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