ABY-029 Head & Neck Trial

Starting soon · Phase 1

Conditions studied: Head and Neck Squamous Cell Carcinoma

In brief

The purposes of the research trial are to study the safety of ABY-029 and to understand how much of the drug is needed to reach head and neck squamous cell carcinomas (HNSCC) so it can be visualized best by surgeons. Investigators will do this by comparing two groups of participants that receive different, very small amounts of ABY-029. Investigators will use an imaging system during surgery to record the amount of ABY-029 in the participant's tumor and in the surrounding tissue.

Key facts

Study ID

NCT07279116

Run by

Dartmouth-Hitchcock Medical Center

People needed

24

Starts

2026-06-30

Expected to finish

2028-06-30

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Preoperative diagnosis of head and neck squamous cell carcinoma with planned surgical resection of the oral cavity, oropharynx, larynx, or hypopharynx.
• Tumor judged to be operable.
• Valid informed consent by participant.
• Age ≥ 18 years old.
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Patients with a medical history of (Grade 2 or higher) hepatic/renal function compromise.
• Prisoners
• Individuals who are pregnant or breast feeding.
• Patients on experimental or approved anti-EGFR targeted therapies.

Full record on ClinicalTrials.gov

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