Frozen Shoulder and Hormone Replacement Therapy

Recruiting now · Phase 4

Conditions studied: Adhesive Capsulitis of the Shoulder, Frozen Shoulder

In brief

The purpose of this study is to determine the effects of hormone replacement therapy (HRT) in addition to standard treatment on frozen shoulder symptoms in women with age-related changes to their menstrual cycle. Frozen shoulder refers to the condition a doctor diagnosed the participant with regarding shoulder pain, stiffness, and progressive loss of range of motion. Age-related menstrual cycle changes, known as perimenopause and/or menopause, refers to a change or stoppage of monthly menstrual cycles. Other symptoms participants may be experiencing include vaginal dryness, hot flashes, or night sweats. Hormone replacement therapy (HRT) refers to medicine with female hormones in it. For this study, HRT will be in the form of a patch that goes on the skin and a daily oral pill. Participants will be randomly assigned to receive either HRT plus standard care, or only standard care. Follow-up tests will be completed at 6 months of treatment to assess participant progress.

Key facts

Study ID

NCT07278323

Run by

University of California, San Francisco

People needed

60

Starts

2026-01-15

Expected to finish

2026-12-01

Last updated by the study team

2026-06-08

Who can join

Age: 40 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of adhesive capsulitis of the shoulder

You may not qualify if…

• History of hormone sensitive cancer
• Bilateral adhesive capsulitis of the shoulder
• Currently using hormonal treatments including contraceptives

Where it is running

• UCSF Orthopaedic Institute — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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