Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity

Recruiting now · Not applicable

Conditions studied: Intrathecal, Dexmedetomidine, Fentanyl, Bupivacaine, Spinal Anesthesia, Above Knee Amputation, Sarcomas, Lower Extremity

In brief

The current work evaluated whether the combination of intrathecal dexmedetomidine and fentanyl provides superior postoperative analgesia to fentanyl alone when administered with hyperbaric bupivacaine.

Key facts

Study ID

NCT07276867

Run by

National Cancer Institute, Egypt

People needed

58

Starts

2025-10-20

Expected to finish

2026-04-01

Last updated by the study team

2025-12-11

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age from 18 to 60 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) physical status of II-III.
• Height between 150-185 cm.
• Body mass index between 18-35 kg/m².
• Scheduled for above-knee amputation due to lower limb sarcomas.

You may not qualify if…

• Allergy to any of the investigated drugs.
• History of heart block, arrhythmia, or ongoing therapy with beta- or calcium channel- blockers, or angiotensin-converting-enzyme inhibitors.
• Contraindications to spinal anesthesia.
• Pregnancy or lactation.
• Presence of psychiatric illness or chronic pain conditions.

Where it is running

• National Cancer Institute — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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