Evaluation of the Relevance of Antithrombin Prescriptions at Strasbourg University Hospitals

Recruiting now

Conditions studied: Antithrombinemia

In brief

Antithrombin (AT) is a physiological inhibitor of the coagulation cascade. In therapeutics, its presence in sufficient quantities is necessary for the pharmacological activity of unfractionated heparin (UFH) and partially low-molecular-weight heparin (LMWH). In intensive care, patients are mostly treated with anticoagulants for either preventive or curative purposes, particularly for those whose care requires renal replacement therapy (RRT), extracorporeal membrane oxygenation (ECMO), or cardiopulmonary bypass (CPB). The use of various types of membranes associated with these procedures can lead to degradation of blood proteins (including AT). An imbalance in hemostasis can then occur, resulting in ineffective anticoagulation. At the Strasbourg University Hospitals (HUS), these medications are directly available in the intensive care units, allowing for immediate administration in an emergency. Pharmaceutical and medical analysis is therefore not performed before administration.

Key facts

Study ID

NCT07276074

Run by

University Hospital, Strasbourg, France

People needed

160

Starts

2024-12-18

Expected to finish

2025-12-31

Last updated by the study team

2025-12-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult subject (≥18 years old)
• Female and male
• Having received antithrombin during the study period, in intensive care or operating room during the period from January 1, 2022 to December 31, 2023.

You may not qualify if…

• Subject (and/or their legal representative, if applicable) having expressed their opposition to the reuse of their data for scientific research purposes
• Minor subject

Where it is running

• Service d'Anesthésie et Réanimation chirurgicale - CHU de Strasbourg - France — Strasbourg, France (enrolling)

Full record on ClinicalTrials.gov

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