Timing and Dose of Fluid Deresuscitation in Critically Ill Patients
Recruiting now
Conditions studied: Fluid Overload, Critical Care, Intensive Care, Deresuscitation
In brief
Fluid deresuscitation is an important intervention in the Intensive Care Unit (ICU). This study aims to find (1) determinants of successful deresuscitation, (2) the optimal rate (dose) of deresuscitation based on these determinants, and (3) differences in metabolic profiles for a more personalized approach of deresuscitation. This study is a multicenter, prospective, observational cohort study in critically ill patients. This study will include ICU patients who have a clinical indication for deresuscitation as set by the treating physician. Clinical, ultrasound and laboratory values will be collected and used for analysis.
Key facts
- Study ID
- NCT07275658
- Run by
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- People needed
- 150
- Starts
- 2025-10-15
- Expected to finish
- 2027-02-28
- Last updated by the study team
- 2026-01-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Admission to one of the participating ICUs;
- Clinical indication for deresuscitation using diuretics or ultrafiltration as set by the treating physician; first attempt during the ICU stay.
You may not qualify if…
- Age below 18 years old;
- Major cardiac shunts;
- Moderate to severe aortic regurgitation;
- Morbid Obesisty (BMI >40);
- POCUS impossible or unreliable (i.e. pre-existing interstitial lung disease);
- PLR or modified form of PLR impossible (i.e. ECMO);
- Transfer from another ICU;
- Previous inclusion in this study;
- Patients who are moribund or facing the end of life;
- Opt out.
Where it is running
- OLVG — Amsterdam, Netherlands (enrolling)
- Amsterdam UMC — Amsterdam, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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