Pregnancy and Fibrin Clot Properties

Recruiting now

Conditions studied: Fibrin Blood Clot, Pregnancy, Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode

In brief

1. The structure of fibrin clot and thrombin generation may vary between trimesters of pregnancy. 2. Unfavorably altered fibrin clot properties along with enhanced thrombin generation may lead to the development of complications during pregnancy such as TE and hypertensive disorders. 3. The application of machine learning techniques may help to identify previously undetected phenotypes with increased risk of TE and hypertensive disorders during pregnancy.

Key facts

Study ID

NCT07275476

Run by

Jagiellonian University

People needed

100

Starts

2025-11-28

Expected to finish

2027-12-01

Last updated by the study team

2025-12-10

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• I. age 18-40 years; II. natural conception (without assisted reproductive techniques).

You may not qualify if…

• I. use of hormonal therapy (i.e., oral contraceptives, progestogens) within 3 months before or during pregnancy; II. use of anticoagulants oral/subcutaneous within 3 months before or during pregnancy; III. increased risk factors of VTE (i.e., obesity - body mass index >30 kg/m2; smoking) or history of VTE; IV. Concomitant diseases, i.e: severe hypertension, diabetes mellitus, autoimmune diseases (i.e., systemic lupus erythematosus, antiphospholipid syndrome); V. congenital or acquired thrombophilia (i.e., mutation factor V Leiden, prothrombin mutation).

Where it is running

• Gynecological Endocrinology Department — Krakow, Małopolska, Poland (enrolling)

Full record on ClinicalTrials.gov

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