Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma

Recruiting now · Not applicable

Conditions studied: Glioblastoma, Brain Tumors, Brain Imaging

In brief

This clinical trial aims to evaluate the feasibility and safety of early post-operative brain PET-MRI imaging in adult patients who have undergone surgery for suspected glioblastoma. The study also seeks to validate specific nuclear imaging parameters for better detection of residual tumor tissue compared to standard gadolinium-enhanced MRI. The main objectives are to determine whether early PET-MRI within 48 hours post-surgery is feasible, to assess potential side effects related to imaging procedures, and to explore if PET parameters such as SUVmax, metabolic volume, and tumor-to-striatum ratio can improve the detection of tumor residue. A total of 15 patients will be included at a single site in France. Participants will undergo PET-MRI using 18F-DOPA and gadolinium, and will be monitored for radiation exposure and possible adverse events up to 24 hours after imaging.

Key facts

Study ID

NCT07274397

Run by

Beta Emitting Accurate Monitored Systems

People needed

15

Starts

2026-04-17

Expected to finish

2027-04-17

Last updated by the study team

2026-06-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• First resection for a suspected glioblastoma in the past 72h
• Signed informed consent
• non-inclusion Criteria:
• Deprived of liberty or under legal protection (e.g, guardianship, trusteeship)
• Patients under 18 years old
• Absence of social security cover
• Pregnancy
• Emergency procedure
• Contraindication to brain MRI, including claustrophobia
• Contraindication to radiotracers or gadolinium injection
• Preoperative cognitive impairment impeding patient information

You may not qualify if…

• Any postoperative behavioral disorders or medical condition or symptom impeding the completion of brain imaging
• Postoperative medical dependency impeding the patient transfer to the nuclear medicine department (including, but not limited to, invasive ventilation, need for external ventricular drainage…)
• Postoperative histological diagnosis different from glioblastoma

Where it is running

• Hôpital Henri Mondor - Université Paris-Est Créteil (UPEC) — Créteil, France (enrolling)

Full record on ClinicalTrials.gov

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