Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic

Recruiting now

Conditions studied: Tick Borne Encephalitis (TBE)

In brief

This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic. The aim is to better understand how individuals recover from TBE, which symptoms may persist after the infection, and which patients may require additional support during their recovery. Participants are examined several times after hospital discharge (at 2-4 weeks, 3 months, 6 months, and 12 months) to observe changes in symptoms, functional status, and daily activities. Follow-up assessments include evaluation of common post-infection problems such as tiredness, headaches, memory or concentration difficulties, sleep issues, or limb weakness. Symptoms lasting for several months are categorized as post-encephalitic syndrome (PES). The study also assesses how TBE affects daily functioning, school and work performance, and overall quality of life using questionnaires and short functional assessments. In addition, the study includes a public-health component that estimates the broader impact of TBE in the population and evaluates the potential benefits of vaccination in preventing long-term health complications. The findings aim to support improved patient care, follow-up planning, and evidence-based public-health decision-making in the Czech Republic.

Key facts

Study ID

NCT07274046

Run by

Charles University, Czech Republic

People needed

209

Starts

2023-04-01

Expected to finish

2026-12-01

Last updated by the study team

2025-12-10

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hospitalization due to suspected central nervous system (CNS) infection.
• Laboratory-confirmed TBE, defined as:
• the presence of CNS symptoms and cerebrospinal fluid pleocytosis (>5 × 10⁶/L) and TBEV IgM and IgG seropositivity in serum, or detection of TBEV IgM in CSF in previously vaccinated individuals.
• All age groups (children and adults).
• Ability to participate in scheduled follow-up (in person or via telephone).
• Informed consent provided by the patient or legal guardian (for minors).

You may not qualify if…

• Alternative diagnosis explaining the CNS symptoms
• Missing essential clinical or laboratory data required to confirm TBE or assess outcomes.
• Refusal or inability to provide informed consent.
• Inability to complete follow-up assessments, including situations where reliable contact cannot be maintained.
• Coexisting severe neurological disorder unrelated to TBE that prevents meaningful evaluation of sequelae (e.g., advanced neurodegenerative disease, severe preexisting motor disability).

Where it is running

• Ostrava University Hospital — Ostrava, Moravian-Silesian Region, Czechia (enrolling)
• Pardubická nemocnice — Pardubice, Pardubice Region, Czechia (enrolling)
• Bulovka University Hospital — Prague, Prague, Czechia (enrolling)
• České Budějovice Hospital — České Budějovice, South Bohemian Region, Czechia (enrolling)

Full record on ClinicalTrials.gov

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