Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score

Recruiting now · Not applicable

Conditions studied: Venous Hemodynamics

In brief

The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting. The impact on the VExUS score of these manoeuvres is unclear. This study aims to assess the effects of PEEP in supine and prone position on the VExUS score as well as echocardiographic parameters in a cohort of healthy volunteers.

Key facts

Study ID

NCT07273617

Run by

University Hospital, Basel, Switzerland

People needed

40

Starts

2025-09-25

Expected to finish

2026-06-01

Last updated by the study team

2025-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Voluntary participants ≥ 18 years in good overall health with no relevant organ dysfunction in their medical history and signed informed consent form.

You may not qualify if…

• Non-French or non-German speakers
• Unable to provide informed consent
• Body mass index > 40kg/m
• Self-reported pregnancy
• History of pneumothorax
• Previously participated in the study

Where it is running

• University Hospital Basel, Intensive Care Unit — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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