Effect of HIIT on Post-Stroke Fatigue

Recruiting now · Not applicable

Conditions studied: Stroke

In brief

This study aims to investigate the effect of high-intensity interval training (HIIT) on fatigue severity among individuals with chronic stroke. Participants will be randomly assigned to the HIIT group, the moderate-intensity continuous training (MICT) group, or the stretching group (active control). Each group will participate in supervised exercise sessions three times per week over a 12-week period, totaling 36 sessions. Outcome assessments will be conducted at baseline, mid-intervention (week 6), post-intervention (week 12), and follow-up (week 20). The primary outcome will be fatigue severity. Secondary outcomes will include inflammatory biomarkers and additional health-related indicators.

Key facts

Study ID: NCT07273058
Run by: The Hong Kong Polytechnic University
People needed: 60
Starts: 2025-10-15
Expected to finish: 2027-10-01
Last updated by the study team: 2025-12-09

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age of 40-80 years;
a history of ischemic stroke resulting in unilateral limb impairment 6-60 months prior to consent to participate in the pilot trial;
a stable medical condition;
a subjective feeling of fatigue, defined as a period of apparent fatigue, decreased energy, increased need for rest, or fatigue out of proportion to physical activity for at least 2 weeks during the past month;
ability to communicate with the investigators and lack of significant cognitive deficits;
able to walk for 10 meters with or without a walking aid.

You may not qualify if…

An FSS score of < 4 (20);
other neurological conditions;
other musculoskeletal comorbidities that would prevent safe participation in exercises;
a medical diagnosis of significant cardiovascular, pulmonary, or metabolic disease(s);
signs or symptoms indicative of significant cardiovascular, pulmonary, or metabolic disease(s) during the previous 3 months;
severe lower limb spasticity (Ashworth Scale score ≥ 3);
Botulinum toxin use in the affected lower limb within the past six months;
current or previous use of drugs intended to resolve post-stroke fatigue;
active engagement in other stroke rehabilitation trials.

Where it is running

The Hong Kong Polytechnic University — Kowloon, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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