Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass

Recruiting now

Conditions studied: Type 2 Diabetes, Obesity, Semaglutide, GLP-1, Diabetes

In brief

The aim of this study is to use advanced MRI scans to track changes in both muscle and fat in the body and heart over a 12-month period in individuals starting semaglutide. By doing so, we hope to gain a clearer understanding of how semaglutide affects muscle health and function. Our goal is to ensure the medication supports long-term well-being, particularly for people who may be at higher risk of muscle loss. This study involves (3) in-person study visits. At each visit, participants will be asked to: * Undergo magnetic resonance imaging (MRI) while resting and during exercise to take pictures of their heart, abdomen, and legs. * Complete tests to assess balance, sit-to-stand, walking speed, and handgrip strength. * Complete questionnaires related to demographics, health information, physical activity, and nutrition. * Have a blood sample collected from a vein in your arm. * Have your blood levels assessed through three finger pricks. * Complete three days of food records.

Key facts

Study ID

NCT07272837

Run by

University of Alberta

People needed

50

Starts

2026-05-15

Expected to finish

2028-04-30

Last updated by the study team

2026-07-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults 18-80 years of age
• Starting semaglutide for type 2 diabetes or weight loss
• Able to safely undergo an MRI scan (including meeting the physical requirements for MRI equipment)

You may not qualify if…

• Current use of semaglutide for more than 2 weeks
• Major recent heart issues or other severe health conditions
• Concerns related to MRI use (including magnetic implants, pacemaker, severe claustrophobia)
• Dependence on a mobility aid (unable to participate in exercise MRI)

Where it is running

• Mazankowski Alberta Heart Institute — Edmonton, Alberta, Canada (enrolling)

Full record on ClinicalTrials.gov

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