Neurocognitive Assessment Platform 4 Alzheimer

Recruiting now

Conditions studied: MCI, MCI Conversion to Dementia, AMCI - Amnestic Mild Cognitive Impairment, Alzheimer Disease

In brief

The aging population in Europe is leading to an increase in neurodegenerative diseases, such as Alzheimer's disease (AD), which is expected to affect 152 million people worldwide by 2050. In Italy, there are approximately 1.2 million cases of dementia, with 600,000 attributed to AD. Given the limited effectiveness of current pharmacological treatments, there is a growing need for early, non-pharmacological interventions to slow disease progression and improve the quality of life for patients and caregivers. The Neurocognitive Assessment Platform 4 Alzheimer (NAP4A) study aims to create a digital platform for the early detection of amnestic mild cognitive impairment (MCIa), considered an intermediate stage between normal aging and dementia. The platform uses non-invasive biometric tools, including EEG, blood flow sensors, and eye-tracking devices, to collect neurophysiological and behavioral data. The study will involve 100 participants aged 55 to 80, divided into two groups: one with individuals diagnosed with MCIa and a control group of healthy participants. Over 12 months, regular assessments will be conducted to identify markers that predict the progression from MCIa to AD. The goal is to develop advanced diagnostic tools that support early and targeted interventions.

Key facts

Study ID

NCT07272811

Run by

IRCCS San Raffaele

People needed

100

Starts

2021-12-15

Expected to finish

2026-06-01

Last updated by the study team

2026-01-22

Who can join

Age: 55 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Rejection of informed consent
• Important sensory deficits (e.g., hearing loss or hypovisus)
• Current or previous history of psychiatric illness
• Current or previous degenerative pathology of the central nervous system (CNS)
• Presence of systemic diseases in anamnesis
• Presence of cerebrovascular events in anamnesis
• Use of alcohol or psychotropic substances in anamnesis

Where it is running

• IRCCS San Raffele — Milan, Italy, Italy (enrolling)

Full record on ClinicalTrials.gov

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