Observational RegIstry of Effectiveness and Safety of teNecTeplase in reAl worLd Settings in China
Recruiting now
Conditions studied: Stroke
In brief
The ORIENTAL study is a prospective, multicenter, continuously enrolled real-world cohort designed to evaluate the effectiveness and safety of intravenous tenecteplase for acute ischemic stroke (AIS) in routine clinical practice across China. Approximately 10,000 patients from about 200 hospitals will be included. Eligible adults with imaging-confirmed AIS who receive tenecteplase as part of standard care will be consecutively enrolled and followed through 90 days. The study will describe patient characteristics, treatment processes, functional outcomes, and safety events, and will also explore inter-hospital variability and subgroup differences to support quality improvement and guide nationwide implementation of tenecteplase therapy.
Key facts
- Study ID
- NCT07271342
- Run by
- Beijing Tiantan Hospital
- People needed
- 10000
- Starts
- 2025-11-30
- Expected to finish
- 2029-06-30
- Last updated by the study team
- 2026-01-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 years or older;
- Diagnosed with acute ischemic stroke confirmed by imaging (CT or MRI);
- Treated with intravenous tenecteplase at the participating institution;
- Provided written informed consent, signed by the patient or their legally authorized representative;
- Capable of completing follow-up assessments.
You may not qualify if…
- Received reperfusion therapy prior to the hospital admission (e.g., intravenous thrombolysis prior to admission);
- Participating in any clinical trials where the intervention may affect the outcomes of this study.
Where it is running
- Beijing Tiantan Hospital, Capital Medical University — Beijing, China (enrolling)
Full record on ClinicalTrials.gov
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