Alii Supplement Study

Completed · Phase 2 · Has a placebo group

Conditions studied: Nutrient Deficiency, Happiness, Digestive Health, Vulnerability to Disease, Mood Swings, Energy

In brief

The goal of this clinical trial is to learn if the Alii Supplement can be used to reduce symptoms related to nutritional depletion in hormonal birth control pill users. The main questions it aims to answer are: Does usage of the supplement increase happiness, decrease perceived vulnerability to disease, increase digestive health, decrease mood swings, and increase energy? The investigators will compare the Alii Supplement to a placebo (a capsule that contains no drug) to see if the Alii Supplement works to reduce symptoms associated with nutritional depletion. Participants will: Take the placebo or Alii Supplement everyday for 28 days and visit the research office twice to fill out an online survey comprising of items examining the main outcome measures.

Key facts

Study ID: NCT07271316
Run by: Texas Christian University
People needed: 16
Starts: 2026-01-12
Expected to finish: 2026-04-20
Last updated by the study team: 2026-07-13

Who can join

Age: 18 and older, up to 25. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Participants must be on the hormonal birth control pill as the investigators are testing the effectiveness of a supplement for women who take the hormonal birth control pill
Participants must be willing to complete a follow up survey as this study will be multiple parts
Participants must be willing to take a daily supplement as this study is testing how a supplement influences a variety of psychological outcomes
Participants must be on the hormonal birth control pill for at least six months as participants who have been on the pill for less than 6 months may not be experiencing nutritional depletion yet
If the investigators are able to do so, the investigators will only recruit participants who take the one-month hormonal birth control pill rather than the three month hormonal birth control pill, as the investigators are going to have participants come in after 28 days (day 2 of pack 1 and day 2 of pack 2) and participants on the three-month HBC pill may be on a 21 day cycle.
Participants must have no food or medication allergies that will prevent the participants from safely taking the supplement
Participants must not be taking any vitamins or participant must report willingness to abstain from taking vitamins during the study as individuals who are already taking vitamins may not be experiencing nutritional depletion associated with hormonal birth control
If the investigators have the ability to do so, the investigators will only recruit participants who are not taking medications. Participants on various medications (e.g., SSRIs, ADHD medications, etc.) may report differing psychological states due to their medications, rather than the supplement. Therefore, it would be best to exclude those individuals if possible.

You may not qualify if…

Participants cannot be naturally cycling as the investigators are testing a supplement for women on hormonal birth control
Participants cannot be unwilling to complete a follow up study because this is a multi-part study
Participants cannot be unwilling to take a supplement because the study centers around taking a supplement
Participants cannot be on the hormonal birth control pill for less than 6 months as participants who have been on the pill for less than 6 months may not be experiencing nutritional depletion yet
If the investigators are able to do so, participants cannot take the three month hormonal birth control pill, as the investigators are going to have participants come in after 28 days (day 2 of pack 1 and day 2 of pack 2) and participants on the three-month HBC pill may be on a 21 day cycle.
Participants cannot have any food or medication allergies that will prevent the participants from safely taking the supplement
Participants must not be taking any vitamins or participants must report willingness to abstain from taking vitamins during the study as individuals who are already taking vitamins may not be experiencing nutritional depletion associated with hormonal birth control
If the investigators have the ability to do so, the investigators will only recruit participants who are not taking medications. Participants on various medications (e.g., SSRIs, ADHD medications, etc.) may report differing psychological states due to their medications, rather than the supplement. Therefore, it would be best to exclude those individuals if possible.

Where it is running

Texas Christian University — Fort Worth, Texas, United States

Full record on ClinicalTrials.gov

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