Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Diabetic Kidney Disease (DKD)
In brief
This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times
Key facts
- Study ID
- NCT07271186
- Run by
- Regeneron Pharmaceuticals
- People needed
- 270
- Starts
- 2026-01-09
- Expected to finish
- 2028-04-07
- Last updated by the study team
- 2026-08-10
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Applied Research Center of Arkansas — Little Rock, Arkansas, United States (enrolling)
- AME Clinical Research — Huntington Beach, California, United States (enrolling)
- Amicis Research Center — Northridge, California, United States (enrolling)
- FOMAT - Vista del Mar Medical Group — Oxnard, California, United States (enrolling)
- Central Coast Nephrology — Salinas, California, United States (enrolling)
- North America Research Institute — San Dimas, California, United States (enrolling)
- Amicis Research Center — Santa Clarita, California, United States (enrolling)
- Valiance Clinical Research — Tarzana, California, United States (enrolling)
- Amicis Research Center — Valencia, California, United States (enrolling)
- National Institute of Clinical Research, Inc. — Victorville, California, United States (enrolling)
- Yale University — New Haven, Connecticut, United States (enrolling)
- D&H Doral Research Center — Doral, Florida, United States (enrolling)
- AGA Clinical Trials — Hialeah, Florida, United States (enrolling)
- Convenient Medical Center — Hialeah, Florida, United States (enrolling)
- Elixia Hollywood — Hollywood, Florida, United States (enrolling)
- D&H Pompano Research Center — Margate, Florida, United States (enrolling)
- LCC Medical Research Institute — Miami, Florida, United States (enrolling)
- D&H National Research Centers, Inc — Miami, Florida, United States (enrolling)
- Regenerate Primary Medical Research, LLC — Miami, Florida, United States (enrolling)
- Ocean Blue Medical Research Center - Internal Medicine — Miami Springs, Florida, United States (enrolling)
- Innovia Research Center — Miramar, Florida, United States (enrolling)
- Central Florida Kidney Specialists Oakwater — Orlando, Florida, United States (enrolling)
- Bolanos Clinical Research — Pembroke Pines, Florida, United States (enrolling)
- Progressive Medical Research — Port Orange, Florida, United States (enrolling)
- Apogee Clinical Research, LLC — Huntsville, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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