Nebulized Nasal Steroids

Starting soon · Phase 1/Phase 2

Conditions studied: Chronic Rhinosinusitis

In brief

The goal of the proposed project is to assess the efficacy, safety, and patient experience of budesonide administered via the NasoNeb system for medical management of CRS. The authors propose a randomized controlled trial of nebulized budesonide via the NasoNeb compared against budesonide lavage.

Key facts

Study ID: NCT07270302
Run by: Washington University School of Medicine
People needed: 50
Starts: 2025-12-01
Expected to finish: 2026-05-01
Last updated by the study team: 2025-12-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age 18 or older that meet diagnostic criteria for CRS with or without polyposis as documented by their recruiting physician.
Diagnostic criteria for CRS will be defined according to EPOS criteria of >12 weeks of 2 of the following subjective symptoms: nasal blockage or obstruction, rhinorrhea, hyposmia, or facial pain/pressure AND objective evidence of CRS on either nasal endoscopy or CT scan

You may not qualify if…

Patients who have previously undergone sinus surgery
Severe polyposis; defined as Lund Kennedy endoscopy score greater than 1
Patients who are currently using or who have previously used biologic medications for their nasal polyps. These medications include: dupilumab, omalizumab, mepolizumab, tezepelumab, or depemokimab
Inability to complete surveys in English
known comorbid mucociliary disease
known adrenal disease or other HPA dysfunction
patients taking oral corticosteroids for other medical conditions
oral antibiotic administration within 2 weeks of study participation
a baseline SNOT-22 score less than 9, due to inability to achieve the MCID

Where it is running

Nyssa Fox Farrell — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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