A Study of Multiparametric Ultrasound Imaging Methods

Recruiting now · Not applicable

Conditions studied: Pancreatic Cancer, Thyroid Nodule

In brief

The researchers are doing this study to see how well a type of ultrasound imaging called multiparametric ultrasound (mpUS), can be used to examine, evaluate, and provide information about different cancerous and non-cancerous tissue. The researchers will compare the results of mpUS imaging to standard ultrasound imaging and other standard tests. mpUS imaging is a type of ultrasound imaging that combines different ultrasound methods and analysis to create a more detailed and accurate assessment of tissue. Standard ultrasound provides a basic image of tissue structure, but mpUS imaging can also show blood vessels, blood flow, and detailed tissue structure (microstructure). The researchers think that mpUS may be a better way for evaluating cancer because it combines different ultrasound methods to assess tissue.

Key facts

Study ID: NCT07270237
Run by: Memorial Sloan Kettering Cancer Center
People needed: 85
Starts: 2025-11-24
Expected to finish: 2027-11-01
Last updated by the study team: 2025-12-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Cohort 1 - Feasibility of multiparametric endoscopic ultrasound (mpEUS) imaging of patients at high-risk for pancreatic cancer:
Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer Participants enrolled into the Memorial Sloan Kettering Cancer Center Pancreatic Registry protocol (IRB#: 02-102) will be eligible for this study. Specifically, related individuals without pancreatic cancer who are at-risk for developing pancreatic cancer and meet all of the following criteria (family health history will be self-reported):
10 years younger than the earliest pancreatic cancer diagnosis in the family
Be at least 50 years old
Be at least 40 years old if diagnosed with FAMMM syndrome (CDKN2A/p16) or Hereditary Pancreatitis (PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate hereditary pancreatitis genes)
Be at least 35 years old if diagnosed with Peutz-Jeghers syndrome (STK11 aka LKB1)
Not pregnant and not Nursing
Relatives at least 21 years old with other high-risk clinical criteria that warrants pancreatic cancer surveillance or follow-up as determined by the project leader (Dr. Vineet Rolston)
Must agree to be contacted for follow-up
Must satisfy at least one of the following 4 criteria:
Have at least two affected relatives who are a first-degree relative to each other, of whom at least one is a first degree relative to the individual OR have at least two affected first-degree relatives on the same side of the family.
Have at least one first- or second-degree affected relative and have germline genetic test results that confirm a likely pathogenic or pathogenic variant in at least one of the following genes:
APC (Familial Adenomatous Polyposis (FAP) and Attenuated FAP syndrome
BRCA1(Hereditary Breast and Ovarian Cancer Symptoms)
MLH1, MSH2, MSH6, PMS2, or EPCAM (Lynch Syndrome)
PALB2
TP53 (Li-Fraumeni Syndrome)
Other established pancreatic cancer predisposition gene per project leader's discretion
Have germline genetic test results that confirm a likely pathogenic or pathogenic variant in one or more of the following genes:
CDKN2A/p16 (Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM))
STK11 aka LKB1 (Peutz-Jeghers Syndrome)
PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate hereditary pancreatitis genes per project leader's discretion
ATM (ataxia telangiectasia mutated)
BRCA 2(Hereditary Breast and Ovarian Cancer Symptoms)
Relatives at least 21 years old with other high-risk clinical criteria that warrants pancreatic cancer surveillance or follow-up as determined the project leader (Dr. Vineet Rolston)

You may not qualify if…

Cohort 2 - Multiparametric endoscopic ultrasound imaging (mpEUS) of patients with pancreatic ductal adenocarcinoma:
Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
Under 18 years of age
Cohort 3 -Thyroid nodule assessment with multiparametric ultrasound (mpUS) imaging
Unable to sign an informed consent for medical or other reasons; residents outside the continental United States
Under 18 years of age

Where it is running

Memorial Sloan Kettering Basking Ridge (Consent Only) — Basking Ridge, New Jersey, United States (enrolling)
Memorial Sloan Kettering Monmouth (Consent Only) — Middletown, New Jersey, United States (enrolling)
Memorial Sloan Kettering Bergen (Consent Only) — Montvale, New Jersey, United States (enrolling)
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) — Commack, New York, United States (enrolling)
Memorial Sloan Kettering Westchester (Consent Only) — Harrison, New York, United States (enrolling)
Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (enrolling)
Memorial Sloan Kettering Nassau (Consent Only) — Uniondale, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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