Effect of Nutritional Supplement Alpha-ketoglutarate for Age-related Ocular Disease

Completed · Early Phase 1

Conditions studied: Eye Diseases

In brief

The aims of the study are as follows: 1. Determine how the eye absorbs supplements taken orally. 2. Look for specific signs in the proteins and substances in the eyes of people with eye diseases who are also taking nutritional supplements.

Key facts

Study ID

NCT07269704

Run by

Stanford University

People needed

17

Starts

2023-08-15

Expected to finish

2025-06-10

Last updated by the study team

2026-04-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able and willing to give written informed consent
• Able to attend all study visits and complete the study procedures
• Women of child-bearing potential must have a negative pregnancy test within 2 weeks before cataract surgery. A pregnancy test is not required for postmenopausal women (defined as being at least 12 consecutive months without menses) or those surgically sterilized (those having a bilateral tubal ligation/bilateral salpingectomy, bilateral tubal occlusive procedure, hysterectomy, or bilateral oophorectomy).

You may not qualify if…

• Diabetes and/or thyroid, liver, kidney, bowel, and metabolic diseases or disorders
• History of supplement allergy or planned major surgery
• Received any other clinical trial drug within 4 months
• Calculated creatinine clearance of less than 30 ml/min

Where it is running

• Byers Eye Institute — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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