Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil
Recruiting now · Not applicable
Conditions studied: Hypertrophic Scars
In brief
The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars? Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies. Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to: * apply the topical application on their scar twice a day for 8 weeks * attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs * immediately inform the researcher if they experience any side effects
Key facts
- Study ID
- NCT07269093
- Run by
- Universiti Sains Malaysia
- People needed
- 120
- Starts
- 2025-12-21
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-01-02
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with traumatic or surgical wounds which have healed by primary intention within 14 days
- Length of scar at least 3cm
You may not qualify if…
- Patients with seafood allergy
- Patients with scar from wounds that were complicated by infection or wound breakdown
- Patients who have undergone scar treatment by other modalities
- Patients with history of keloids / hypertrophic scars
- Pregnant patients
Where it is running
- Hospital Pakar Universiti Sains Malaysia — Kubang Kerian, Kelantan, Malaysia (enrolling)
- Hospital Raja Perempuan Zainab II — Kota Bharu, Kelantan, Malaysia
- Hospital Kuala Lumpur — Kuala Lumpur, Kuala Lumpur, Malaysia
Full record on ClinicalTrials.gov
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