Heartburn, Gastroesophageal Reflux Disease

Recruiting now · Phase 4

Conditions studied: GERD

In brief

Gastroesophageal reflux disease (GERD) is a condition caused by the reflux of stomach contents into the esophagus, presenting with typical symptoms such as heartburn and acid regurgitation. GERD is a chronic condition that affects quality of life, and patients with this condition are known to have a lower quality of life compared to healthy individuals. In particular, nocturnal heartburn can lead to sleep deprivation and affect daily life, as well as overall quality of life. This study aims to evaluate the efficacy of alleviating nocturnal heartburn symptoms in patients with erosive reflux disease (ERD).

Key facts

Study ID

NCT07268820

Run by

Incheon St.Mary's Hospital

People needed

160

Starts

2025-07-07

Expected to finish

2026-09-30

Last updated by the study team

2025-12-23

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Korean adults aged 19 years or older as of the date of written consent
• Those diagnosed with erosive gastroesophageal reflux disease based on upper gastrointestinal endoscopy (EGD)
• Those who reported nighttime heartburn for more than 3 months at the time of screening (Visit 1)
• Those who voluntarily decided to participate and provide written informed consent

You may not qualify if…

• Those who cannot undergo upper gastrointestinal endoscopy (EGD)
• Individuals with a history of drug or alcohol abuse (within the past year)
• Individuals who have received other investigational products within one month prior to the screening visit (Visit 1)
• In addition to the above, individuals with clinically significant findings that the investigator deems medically inappropriate for the present study

Where it is running

• Korea University Ansan Hospital — Ansan, South Korea (enrolling)
• Pusan National University Hospital — Busan, South Korea (enrolling)
• Kyungpook National University Chilgok Hospital — Chilgok, South Korea (enrolling)
• Hallym University Chuncheon Sacred Heart Hospital — Chuncheon, South Korea (enrolling)
• Chonnam National University Hospital — Gwangju, South Korea (enrolling)
• Catholic University of Korea, Incheon ST. Mary's Hospital — Incheon, South Korea (enrolling)
• Gangnam Severance Hospital — Seoul, South Korea (enrolling)
• Kyung Hee University Hospital — Seoul, South Korea (enrolling)
• Soonchunhyang University Hospital — Seoul, South Korea (enrolling)
• Pusan National University Yangsan Hospital — Yangsan, South Korea (enrolling)

Full record on ClinicalTrials.gov

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