1-hour Premedication for Allergy Goal in Emergency: PAGE-1 Study
Starting soon · Not applicable
Conditions studied: Allergic Reaction to Contrast Media, Hypersensitivity Reaction, Computed Tomography, Premedication
In brief
1-hour Premedication for Allergy Goal in Emergency: PAGE-1 is a prospective, parallel, two-arm, non-inferiority, randomized controlled trial evaluating the safety of a 1-hour (intervention) versus a 4-hour (standard regimen) intravenous (IV) premedication protocol in adult patients in the Emergency Department (ED) with a documented iodinated contrast allergy and requiring computed tomography (CT) imaging for a high-risk indication.
Key facts
- Study ID
- NCT07268248
- Run by
- Paul Peng, MD PhD MSCR
- People needed
- 540
- Starts
- 2026-06-01
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-02-19
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult (≥ 21 years old)
- Documented iodinated contrast allergy in the electronic health record
- CT with iodinated contrast ordered for a high-risk indication, † defined as post-arrest, concern for aortic dissection, ischemia, occlusion, obstruction, or other life-threatening conditions requiring timely diagnosis
- Willing and able to give consent
You may not qualify if…
- Previous enrollment in this study
- Pregnancy
- Seafood or iodine allergy, alone
- Gadolinium allergy
Full record on ClinicalTrials.gov
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