Acute Effects of Transcutaneous Electrical Nerve Stimulation at Acupoints on Nociceptive Transmission

Recruiting now · Not applicable

Conditions studied: Pain Management

In brief

The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation (TENS) applied to acupoints can modulate pain transmission and cortical processing in healthy adult volunteers. The main questions it aims to answer are: * Does TENS at Zhongzhu (SJ3) and Hegu (LI4) change pain-related evoked potentials (PREPs)? * Does acupoint electrical stimulation alter nociceptive pathways reflected by PREP waveform modulation? Researchers will compare PREPs recorded before and after TENS at the two acupoints to see if TENS produces measurable effects on cortical nociceptive responses. Participants will receive low-frequency TENS applied to Zhongzhu (SJ3) and Hegu (LI4), and undergo PREP assessments before and after the intervention to measure cortical responses to standardized noxious stimuli.

Key facts

Study ID

NCT07267052

Run by

China Medical University Hospital

People needed

35

Starts

2025-09-05

Expected to finish

2026-07-31

Last updated by the study team

2026-07-08

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy Adult
• 20 years or older
• The absence of chronic medical conditions
• No history of drug allergies
• No skin disorders
• No current use of medications that could affect study outcomes
• Participants maintain a regular daily routine
• No history of substance or medication abuse

You may not qualify if…

• History of malignant tumors
• History of hand disorders
• Has implanted cardiac pacemakers
• Pregnancy
• Epilepsy
• Any other condition that may interfere with the study procedures

Where it is running

• Department of Physical Therapy of China Medical University — Taichung, Beitun, Taiwan, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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