Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness

Starting soon · Not applicable · Has a placebo group

Conditions studied: Gulf War Syndrome

In brief

The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage. The investigators believe that GWI involves inflammation in the body and brain that causes fatigue, pain, cognitive disruption, and other symptoms. Botanicals that reduce inflammation may help treat GWI.

Key facts

Study ID: NCT07266571
Run by: University of Alabama at Birmingham
People needed: 20
Starts: 2026-08-01
Expected to finish: 2027-08-01
Last updated by the study team: 2026-06-17

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

Meet the Kansas GWI case definition
Meet the CDC GWI case definition
Able to commit to a 12-month study
Male
Participants will be individuals in our Gulf War database who have already completed our other botanical trial, Curcumin, Resveratrol, and Stinging Nettle as Treatments for Gulf War Illness (NCT05377242).

You may not qualify if…

Currently involved in another experimental treatment study
Female
Have a blood clotting disorder
Reported diagnosis of diabetes with a A1C greater than 9
Use of contraindicated medications (see below):
Anticoagulants (such as warfarin, heparin, etc.)
Lithium
Tacrolimus (Prograf)
Cancer medications (Alkylating agents, antitumor antibiotics, Topoisomerase I inhibitors, Tamoxifen)
Daily Use of Antiplatelet agents (e.g. aspirin, clopidogrel)
Nitroglycerin
Hypotension
Need for surgery during study period.

Where it is running

University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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