Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients

Recruiting now · Not applicable

Conditions studied: Orthopaedic Related Pain (Musculoskeletal Pain), Opioid, Pain, Pilot Study

In brief

This is a single-center, pilot randomized controlled trial designed to evaluate the feasibility of a definitive trial comparing opioid-free discharge prescriptions to usual care (which includes opioids) in patients undergoing major orthopaedic surgery. The main objective is to inform the design and feasibility of the definitive RCT.

Key facts

Study ID

NCT07265557

Run by

Massachusetts General Hospital

People needed

100

Starts

2025-10-06

Expected to finish

2026-12-31

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18 years of age or older
• Underwent a major operative orthopaedic procedure

You may not qualify if…

• Contraindication for NSAIDs.
• Preoperative chronic opioid use (preoperative use of >14 days and average of >30 Morphine Milligram Equivalents per day).
• Active treatment for opioid use disorder.
• Previous or current illicit drug use.
• Major surgery for pathologic (cancer-related) condition.
• Hand surgery.
• Concurrent operative treatment by another specialty team.
• Discharged to an extended medical care facility.
• Incarceration.
• Women who are pregnant or planning to become pregnant in the next 6 weeks.
• Expected injury survival of less than 6 weeks.
• Terminal illness with expected survival of less than 6 weeks.
• Anticipated problems, in the judgment of research personnel, with maintaining follow-up with the patient.
• Currently enrolled in a trial that does not permit co-enrollment.
• Prior enrollment in the trial.
• Unable to obtain informed consent.
• Non-English speaking
• Eligible patient was not approached prior to hospital discharge (missed participant).
• Did not provide informed consent (declined participation).
• Other reason to exclude the patient, as approved by the Principal Investigator

Where it is running

• Mass — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.