Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition

Recruiting now · Not applicable

Conditions studied: Alzheimer s Disease, Alzheimer Blood Biomarkers, Insulin Sensitivity

In brief

The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.

Key facts

Study ID

NCT07265323

Run by

Pennington Biomedical Research Center

People needed

8

Starts

2025-12-01

Expected to finish

2027-05-01

Last updated by the study team

2025-12-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mini Mental State Examination (MMSE) score < 25

You may not qualify if…

• On daily medication for the specific treatment of anxiety including benzodiazepines.
• An infant, child, or teenager
• A pregnant woman
• A prisoner
• Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States (enrolling)

Full record on ClinicalTrials.gov

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