Real-Time Dynamic Imaging Study of Normal Pharyngolaryngeal Structures During Barium Swallow (GLAM-III)

Recruiting now

Conditions studied: Barium Meal Examination

In brief

The integrity and functional stability of pharyngolaryngeal anatomical structures are critical for airway management, and the dynamic changes of key structures (e.g., pyriform sinus, cricoid cartilage lamina) during swallowing directly relate to the design and clinical safety of laryngeal masks. This observational study aims to investigate the real-time dynamic changes and physiological movement patterns of normal pharyngolaryngeal structures during barium swallow using routine barium meal examination imaging. The findings will provide anatomical and physiological evidence for optimizing laryngeal mask design and improving its anatomical fit with the pharynx and larynx.

Key facts

Study ID

NCT07264322

Run by

Zhejiang Cancer Hospital

People needed

3

Starts

2025-09-10

Expected to finish

2025-12-30

Last updated by the study team

2025-12-04

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18-75 years;
• No history of pharyngolaryngeal surgery, trauma, or congenital malformation;
• No swallowing dysfunction, pharyngolaryngeal inflammation, or neurological diseases affecting swallowing;
• No recent use of drugs that affect muscle function (e.g., muscle relaxants, anticholinergics);
• Barium meal examination confirms unobstructed oropharyngeal-esophageal pathway;
• Normal pharyngolaryngeal anatomical structure (confirmed by preliminary imaging review);
• Scheduled to undergo routine barium meal examination at Zhejiang Cancer Hospital for clinical diagnosis.

You may not qualify if…

• Presence of diseases that may compress pharyngolaryngeal structures (e.g., goiter, mediastinal mass);
• Allergy to barium sulfate or other components of the barium suspension.

Where it is running

• Jiangling Wang — Hangzhou, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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