Identifying the Best Follow up Approach for People Who Have Had Treatment to Cure Newly Diagnosed Prostate Cancer

Starting soon

Conditions studied: Prostate Cancer

In brief

Over 20,000 patients a year in the UK get surgery or radiotherapy to cure their prostate cancer. These men then undergo regular check-ups to manage potential side effects and see if cancer recurs so it can be treated quickly. The organisation of these check-ups varies across the country as it is not known which approach is best. The four different established approaches are (i) check-ups performed in hospital outpatients by the same team that provided treatment; (ii) patients seen regularly by their GP with hospital referral as necessary; (iii) planned shared care between general practice and hospital follow up; or (iv) patients supported to provide checks on themselves (self-care) and reaching out to a doctor or a nurse when required. This study will compare these options to establish which is best for patients and makes the best use of the NHS resources.

Key facts

Study ID

NCT07264088

Run by

Imperial College London

People needed

100000

Starts

2026-10-01

Expected to finish

2027-07-01

Last updated by the study team

2026-04-16

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• All hospitals in England that provide radical prostatectomy or radical radiotherapy or focal therapy for prostate cancer and are identified by clinicians as receiving one of the four follow up strategies of interest will be eligible for inclusion in the study.
• Individual patients satisfying the following criteria will be eligible for inclusion:
• Having newly-diagnosed non-metastatic, clinically localised prostate cancer (ICD-10 code C61) in the Cancer Registry between 1 January 2018 and 31 December 2023;
• Age 18 or over at diagnosis;
• Completed primary curative treatment at an eligible hospital between 1 January 2019 and 31 December 2023 with either: radical radiotherapy +/- hormones, or radical prostatectomy with curative intent +/- lymphadenectomy, or focal therapy, in keeping with local practice;
• Alive with no disease progression or metastasis 6 months after the date of completion of primary curative treatment.

You may not qualify if…

• Men who are treated for metastatic cancer; or receiving palliative prostate cancer care;
• Men who have opted out of their data being used as part of national routine data sets will be excluded (https://digital.nhs.uk/services/national-data-opt-out).
• Recruitment to the survey component of the study will be limited to a sub-cohort of eligible participants that additionally meet the following criteria:
• Alive;
• Have achieved between three to four and a half years of follow up (from completion of initial curative treatment) during the survey period.

Where it is running

• London School of Hygiene & Tropical Medicine — London, United Kingdom

Full record on ClinicalTrials.gov

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