Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study

Recruiting now · Not applicable

Conditions studied: Periodontis, Atherosclerosis Cardiovascular Disease

In brief

Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses. Recent evidence suggests a possible link between severe periodontitis and cardiovascular diseases through shared inflammatory pathways. The PAROCAR study aims to evaluate the association between generalized periodontitis (stages 3 and 4, 2017 Chicago Classification) and arterial stiffness measured by pulse wave velocity (PWV), compared to matched controls without periodontitis, adjusted for conventional cardiovascular risk factors.

Key facts

Study ID

NCT07263113

Run by

Nantes University Hospital

People needed

206

Starts

2026-04-10

Expected to finish

2027-12-01

Last updated by the study team

2026-06-23

Who can join

Age: 40 and older, up to 69. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 40-69 years
• Minimum of 12 teeth (3 per quadrant)
• Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium

You may not qualify if…

• Patients diagnosed with diabetes,
• Patients diagnosed with hypertension or with a history of severe cardiovascular disease,
• Patients diagnosed with familial hypercholesterolaemia,
• Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results,
• Patients with a BMI ≥ 30 kg/m²,
• Patients who have previously undergone periodontal treatment,
• Patients who consume more than 2 units of alcohol per day,
• Patients who refuse to participate in the study,
• Minors and patients under the age of 40,
• Adult patients under legal protection (guardianship, curatorship),
• Patients deprived of their liberty,
• Pregnant or breastfeeding women,
• Patients not affiliated with a health insurance scheme (AME)
• Patients already included in another interventional study

Where it is running

• CHU de Nantes — Nantes, France (enrolling)

Full record on ClinicalTrials.gov

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