The Impact of Preoperative Nutrition Intervention on Muscle Mass Preserve in Older Adults Undergoing Elective Surgery

Starting soon

Conditions studied: Nutrition Status

In brief

Sarcopenia-the progressive loss of muscle mass and strength-is a major clinical issue, especially in surgical patients with malignancy. It's strongly linked to poor postoperative outcomes like increased complications, longer hospital stays, and higher mortality. Surgical stress (trauma, fasting, immobilization) significantly worsens this muscle catabolism. Consequently, early identification and targeted preoperative intervention are essential. Preoperative nutrition, part of a prehabilitation program, is a key strategy known to attenuate muscle loss and improve recovery. The Skeletal Muscle Index (SMI) is an objective metric used for risk stratification. The Siriraj Integrated Preoperative and Prehabilitation Center (SiPAP) uses a multidisciplinary model with nutritional counseling, but lacks routine sarcopenia screening or objective SMI measurement. Therefore, the impact of their specific nutritional interventions on preserving muscle mass remains unevaluated. Hypothesis: The structured, individualized preoperative nutritional intervention delivered by SiPAP to intraabdominal oncology patients will result in a net preservation or positive change in the Skeletal Muscle Index (SMI) over the preoperative period.

Key facts

Study ID

NCT07262034

Run by

Siriraj Hospital

People needed

62

Starts

2026-04-01

Expected to finish

2028-12-01

Last updated by the study team

2026-03-06

Who can join

Age: 60 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 60 years to 90 years
• Schedules for elective major surgery and formally enrollment in the Enhanced Recovery After Surgery (ERAS) program at Siriraj Hospital. (At Siriraj Hospital, patients scheduled for pre-specific elective major surgeries are enrolled into the ERAS program as individual hospital protocols for each ERAS module. All patients are informed about the ERAS program by their surgical team.)
• Referred to the SiPAP center for prehabilitation based on established ERAS hospital preoperative protocol.
• Able to provide written informed consent and willing to undergo all research assessments at both time points.

You may not qualify if…

• Presence of conditions that interfere with bioelectrical impedance analysis (BIA), including an implanted pacemaker or other non-removable electronic medical devices.
• Use of medications or supplements known to acutely or chronically affect muscle mass (e.g. corticosteroids, hormonal therapies) during the study period.
• Diagnosed neuromuscular disorders that affect baseline muscle mass and strength
• Undergo emergency surgery
• A planned interval of less than 14 days between the initial SiPAP visit and hospital admission for surgery.
• Alcohol consumption or strenuous exercise within the 12 hours preceding the scheduled BIA measurement.
• Incomplete data on muscle mass or nutritional assessment at either time point.

Where it is running

• Siriraj Integrated Preoperative And Prehabilitation Center : SiPAP — Bangkok Noi, Bangkok, Thailand

Full record on ClinicalTrials.gov

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