CRP and Patient Information Leaflets to Optimise Antibiotic Treatments for Adults With Respiratory Tract Infections in Primary Care in Kyrgyzstan
Recruiting now · Not applicable
Conditions studied: Respiratory Tract Infection Bacterial, Respiratory Tract Infection Viral, AMR, CRP, Inflammation
In brief
This study aims to determine how CRP levels and Patient Information Leaflets (PILs) affect antibiotic prescribing in adults with acute respiratory symptoms in Kyrgyz primary care. It will evaluate the effectiveness of PILs in reducing antibiotic use and ensuring safety and assess the effectiveness and safety of three CRP thresholds (20, 40, 60 mg/L) for adults with acute respiratory tract infections. Conducted as a multicentre, open label, individually randomized controlled clinical trial with 21 days of blinded follow-up, the study will compare PIL to no PIL in a 1:1 ratio and assess antibiotic use and safety across the three CRP cut-offs in a 1:1:1 ratio, resulting in six groups. The trial will take place in 14 district primary healthcare centres in rural Kyrgyzstan and one urban primary healthcare centre in Bishkek.
Key facts
- Study ID
- NCT07261969
- Run by
- Rigshospitalet, Denmark
- People needed
- 1050
- Starts
- 2024-12-18
- Expected to finish
- 2027-04-30
- Last updated by the study team
- 2025-12-03
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 to 70 years with ARTI according to the attending HCW;
- Having at least one of the following respiratory symptoms lasting for less than 2 weeks (with or without a fever):
- cough;
- shortness of breath;
- sore throat;
- stuffy nose;
- wheezing.
- Able and willing to comply with all study requirements.
- Able and willing to give informed consent.
You may not qualify if…
- Severely ill and in need of urgent referral where measurement of POCT CRP is not relevant or would delay the process;
- Terminally ill patients;
- Patients with known immunosuppression or severe chronic disease (HIV, liver failure, kidney failure, history of neoplastic disease, long term systemic steroid use or similar conditions as assessed by the health worker or research team);
- Patients who are not able to participate in follow-up procedures (lack of telephone etc.);
- Have taken antibiotics within 24 hours before the index consultation;
- Pregnant women;
- Unable or unwilling to provide informed consent.
Where it is running
- Sokuluk Family Medicine Center — Sokuluk Village, Chui Region, Kyrgyzstan (enrolling)
- Azim Azhybek uulu — At-Bashy Village, Naryn Region, Kyrgyzstan (enrolling)
Full record on ClinicalTrials.gov
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