Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial

Starting soon · Phase 2/Phase 3

Conditions studied: Vulvodynia, Dyspareunia, Lichen Sclerosus of Vulva

In brief

We are looking to see if patients using both topical testosterone and estrogen will have a greater improvement in pain with vaginal penetration compared to those using topical estrogen alone.

Key facts

Study ID

NCT07260825

Run by

TriHealth Inc.

People needed

44

Starts

2025-12-01

Expected to finish

2026-08-01

Last updated by the study team

2025-12-03

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older
• Patients with vulvodynia who present with pain (with vaginal penetration) rating score of 4 or greater

You may not qualify if…

• Active vaginal infection
• Pregnancy
• Breast-feeding
• Taking anti-androgenic medication (finasteride, dutasteride)
• Using any other topical hormones to the vulva or vagina

Where it is running

• Cincinnati Urogynecology Associates — Cincinnati, Ohio, United States
• TriHealth — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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