Clinical Comprehensive Evaluation of Neuroprotective Drugs for Acute Ischemic Stroke
Starting soon
Conditions studied: Acute Ischemic Stroke
In brief
This study conducted a comprehensive evaluation of commonly used neuroprotective agents in acute ischemic stroke, assessing their real-world value across six dimensions: safety, efficacy, cost-effectiveness, innovativeness, appropriateness, and accessibility. Employing a prospective observational design, it primarily investigates the association of edaravone and dexrazoxane with clinical outcomes in patients with mild-to-moderate stroke, with subgroup analyses performed according to Trial of Org 10172 in Acute Stroke Treatment （TOAST ）classification.
Key facts
- Study ID
- NCT07260760
- Run by
- Qianfoshan Hospital
- People needed
- 600
- Starts
- 2026-01-20
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-01-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1: Age≥18
- 2: Acute ischemic stroke in the anterior circulation occurring within 48 hours
- 3: Baseline NIHSS score of 1-15 points (mild stroke: baseline NIHSS score of 1-5 points; moderate stroke: baseline NIHSS score of 6-15 points)
- 4: Pre-onset mRS score≤1
- 5: Use of Edaravone (injection or tablets)
- 6: Exclude intracranial hemorrhage
- 7: Sign the informed consent form
You may not qualify if…
- 1: A head CT or MRI scan indicates the presence of intracranial hemorrhagic disease
- 2: Patients with cerebral embolism or suspected cerebral embolism who also have severe atrioventricular block, atrial fibrillation, myocardial infarction, valvular heart disease, infective endocarditis, or a heart rate below 50 beats per minute
- 3: Abnormal liver function (ALT or AST transaminase levels exceeding the upper limit of normal), abnormal kidney function (creatinine levels exceeding the upper limit of normal), or individuals with other severe systemic diseases, etc
- 4: Allergy to the test drug
Full record on ClinicalTrials.gov
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