Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Thermal Burns

Recruiting now

Conditions studied: Burns

In brief

This observational pilot study aims to establish criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS device in adult patients with burn injury. Participants will be prospectively enrolled into the treatment group and compared with a retrospectively selected control group. Each patient in the treatment group will undergo two hemoadsorption sessions, each lasting 6-12 hours, with a 24 hours interval between sessions. The procedures may be performed in combination with hemofiltration or hemodiafiltration at the investigator's discretion.

Key facts

Study ID: NCT07259668
Run by: Efferon JSC
People needed: 15
Starts: 2025-12-08
Expected to finish: 2028-03-31
Last updated by the study team: 2026-01-22

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Thermal burn of Ⅱ and Ⅲ severity with a lesion area of 40% or more (ICD-10: T20-T25, T29)
Burn disease in the stage of acute toxemia or septicemia
Frank Index ≥ 90 (Frank Index quantifies burn severity based on the depth and total surface area of the skin lesion)
The patient's condition allows for Efferon LPS therapy for at least 6 hours

You may not qualify if…

Isolated thermal inhalation injury
Charlson Comorbidity Index > 8
Dementia
End-stage renal failure
Acute pulmonary embolism confirmed by CT
Acute myocardial infarction within the past 4 weeks
Acute cerebrovascular accident
Uncontrolled bleeding (acute blood loss within the past 24 hours)
Any other condition which, in the opinion of the investigator, makes the patient unsuitable for inclusion in the study

Where it is running

State Novosibirsk Regional Clinical Hospital — Novosibirsk, Russia (enrolling)

Full record on ClinicalTrials.gov

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