Predictors of Emergency Department Use in Frail Patients

Recruiting now

Conditions studied: Alzheimer s Disease, Vascular Dementia, Frailty, Elderly, Emergency Department Visits, Autonomy

In brief

When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed. While cognitive impairment is a known clinical risk factor, biomarkers of most prevalent dementias have been scarcely investigated as possible ED use predictors. Within this context, this prospective study aims at exploring whether plasma phospho-tau181 and cerebrovascular burden can predict ED use at 6 months in elderly non-autonomous patients, irrespective of frailty.

Key facts

Study ID

NCT07259499

Run by

University of Pisa

People needed

110

Starts

2023-11-19

Expected to finish

2025-12-31

Last updated by the study team

2025-12-02

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• fluency in Italian language,
• age higher than 64 years,
• loss of autonomies of daily living as assessed by the Katz Activities of Daily Living or in the Lawton Instrumental Activities of Daily Living questionnaires,
• having performed routinary blood exams in the 6 months prior to recruitment
• having performed head neuroimaging feasable for cerebrovascular burden assessment, i.e., Magnetic Resonance Imaging (MRI) or computed tomography (CT), in the 6 months prior to recruitment.

You may not qualify if…

• withdrawal of the informed consent

Where it is running

• Azienda Ospedaliera Universitaria Pisana — Pisa, Pisa, Italy (enrolling)

Full record on ClinicalTrials.gov

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